A Case of Severe HIV-Associated Psoriasis Successfully Treated with Acitretin Therapy
نویسندگان
چکیده
Psoriasis is a chronic inflammatory skin disease that involves immune-mediated cutaneous inflammation and keratinocyte hyperproliferation. Psoriasis in patients with HIV responds poorly to treatment and has a high morbidity rate, thus posing a challenge to clinicians. Until now, there have been no documented cases of acitretin therapy for HIV-associated psoriasis in Korea. Here, we report a case of safe and successful therapy with acitretin in a 52-year-old man with HIV-associated psoriasis that responded poorly to previous treatments including steroids and ultraviolet B phototherapy. We also review the relevant literature.
منابع مشابه
Conditions in Patients With CD4+ Cell Counts Below 200/μL Who Are Not on Antiretroviral Therapy
With the institution of antiretroviral therapy, psoriasis can be controlled with topical treatments, such as clobetasol and calcipotriene and ultraviolet light. Before adequate immune reconstitution under antiretroviral therapy occurs or in cases of complex or more severe psoriasis, treatment with the retinoid agent acitretin at 10 to 25 mg/d can be considered; it should be noted that this agen...
متن کاملCombining systemic retinoids with biologic agents for moderate to severe psoriasis.
BACKGROUND Moderate to severe psoriasis, which is defined as psoriasis affecting more than 20% of the body surface area, often requires a combination of therapies to achieve remission. Although numerous data exist regarding the use of acitretin and biologic agent therapy alone for psoriasis, little is known about the efficacy, safety, and tolerability of acitretin combined with biologic agents....
متن کاملEfficacy of acitretin in severe psoriasis.
Acitretin (Soriatane, Roche Pharmaceuticals) is an aromatic retinoid, effective in the treatment of severe psoriasis. This study highlights data from two existing clinical trials to capture PASI 50 and PASI 75 responder rates which represent a common metric used in current psoriasis clinical trials. A review of pharmacokinetics, safety and a discussion of relapse rate establish acitretin as an ...
متن کاملEtanercept as prophylactic psoriatic therapy before interferon-alpha and ribavirin treatment for active hepatitis C infection.
Patients with psoriasis and chronic hepatitis C virus (HCV) infection are a therapeutic challenge. Systemic psoriasis treatment with methotrexate and acitretin can be hepatotoxic, and interferon (IFN)-alpha for treatment of HCV can worsen psoriasis. Etanercept can be successfully used in patients with psoriasis and HCV. To our knowledge, this is the first case report of etanercept used prophyla...
متن کاملComparison of bath PUVA and Acitretin in treatment of Psoriatic patients
Background: Psoriasis treatment is very important regard to mental sequeler and creating morbidity. First line treatment of generalized plaque type psoriasis includes methotrexate, phototherapy and retinoids. Objective: To compare bath-PUVA and acitretin in the treatment of generalized plaque type psoriasis. Patients and Methods: 40 patients with generalized plaque type psoriasis with PAS...
متن کامل